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Starting Chemotherapy? Here’s How to Prepare Your Body, Mind and Support System

Author
by Luminis Health
June 1, 2026
General - Tier 3 Section
Starting Chemotherapy? Here’s How to Prepare Your Body, Mind and Support System

If you’re preparing for your first chemotherapy treatment, it’s normal to have questions about what’s ahead. Knowing what to expect—and how to prepare—can help you feel more focused and in control.

Understanding the infusion experience

Most treatments take place in an infusion center or hospital and last a few hours. Consider wearing comfortable, loose-fitting clothing and bring these items with you:

  • A list of your medications, and any questions you have for the care team
  • A sweater or blanket to keep you warm
  • Books or music to keep you relaxed and provide a way to pass the time
  • Snacks and water

When you arrive at one of Luminis Health’s two infusion centers, a member of your care team will get you settled and review your treatment plan. If you’re receiving chemotherapy through an IV, a nurse will place a small needle into a vein, usually in your arm. If you have a port, they will access it instead. You may feel a quick pinch or slight pressure during this step.  

Once your treatment begins, the medication will slowly flow into your bloodstream, while you sit or lie in a comfortable chair. Most don’t feel the medication as it enters their body, but some experience mild sensations, such as coolness during the IV infusion or a metallic taste in their mouths.  

If you feel uncomfortable at any point, let your care team know right away.

Managing common side effects

Chemotherapy can cause side effects because it targets fast-growing cells in your body. While the side effects may sound unpleasant, many of them can be managed with simple strategies. Here are some common side effects, and what you can do to feel more comfortable:

  • Changes in appetite or taste: You may notice that foods taste different or that you’re less interested in eating. Try small, frequent meals and choose foods that sound appealing. Staying hydrated and experimenting with different flavors or textures can also make eating manageable. At Luminis Health, dietitians are available to work with you on meeting your body's nutritional requirements.
  • Fatigue: It’s common to feel tired during treatment, even after resting. Try to save your energy for the most important tasks and plan to rest throughout the day. Light activity, like short walks, may also help if your doctor approves.
  • Hair loss: Certain types of chemotherapy can cause hair loss. Knowing what to expect and making a plan can help you feel more prepared. Some choose to cut their hair short before treatment begins or explore options like scarves, hats or wigs—these things can help you feel more like yourself during treatment. Luminis Health offers a free wig boutique for those experiencing hair loss. You may also want to ask about scalp cooling, which can prevent hair loss.
  • Nausea and vomiting: Some treatments upset your stomach. Eating small, frequent meals and sipping water throughout the day can reduce nausea. Your doctor can also prescribe medication if you need additional relief.
  • Weakened immune system: Chemotherapy can lower your body’s ability to fight infections. It’s important to wash your hands often and well, and to avoid close contact with anyone who is sick.

Building your support system

You don’t have to go through chemotherapy alone. Family, friends and caregivers can play an important role in supporting you during treatment. Talk openly with the people you trust about your experiences and be specific about your needs.

A wide range of medical and community resources can also help you through treatment and support your overall well-being. Support groups can connect you with people who understand what you’re going through. A Luminis Health social worker can help you find a group that’s the right fit for you, and connect you to a variety of resources.

Knowing when it’s time to call your care team

Some side effects are expected, but others may need medical attention.  

Contact your care team if you experience any symptoms that concern you, including:

  • Fever or sudden chills
  • Severe nausea or vomiting
  • Signs of infection, such as redness or swelling

If something doesn’t feel right, ask questions or check in with your medical team.

Celebrating resilience during National Cancer Survivors Month

As you prepare for chemotherapy, remember that you’re not alone — and that each treatment is a step toward healing. During National Cancer Survivors Month, we recognize the strength of those undergoing and completing their treatment. 

To learn more about chemotherapy at Luminis Health, please click here.

Authors

Samah NassereddineSamah Nassereddine, MD, is an associate program director for the hematology oncology fellowship at Luminis Health Anne Arundel Medical Center. 

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